冠状动脉病变与糖尿病及高敏C反应蛋白关系的探讨

SERUM HIGH-SENSITIVITY C-REACTIVE PROTEIN LEVEL IN PATIENT WITH CORONARY HEART DISEASE COMPLICATING WITH OR WITHOUT TYPE 2 DIABETIC MELLITUS

目的:探讨冠状动脉病变与糖尿病、血清高敏C反应蛋白(hsCRP)水平之间的关系。方法:对2004年4月至2006年4月四川省泸州医学院附属医院就诊的200例临床怀疑冠心病的患者进行冠状动脉造影,将其中冠状动脉狭窄大于50%诊断为冠心病的164例患者,按照中国糖尿病诊断标准分为糖尿病组(n=68)和血糖正常组(n=96)。对两组同时进行hsCRP水平的测定。两组的冠状动脉造影和hsCRP结果进行组内及组间统计学分析。结果:不同hsCRP水平下冠状动脉病变支数的比较表明,随着hsCRP水平的升高,糖尿病组的冠状动脉病变严重程度加重,差异有统计学意义,特别是在hsCRP>3.0μg/ml时,这种差异尤其明显。结论:hsCRP可以作为预测糖尿病合并冠状动脉粥样硬化性心脏病患者冠状动脉病变严重程度的预测指标。

Objective： To observe the relationship between serum high- sensitivity C-reactive protein （hsCRP） level ,coronary artery lesion and type 2 diabetes. Method：164 cases of coronary heart disease were cliagnosed from 2004 .to 2006.4 in affliliated hospital of Lu Zhou Medical College because of chest pain confirmed by coronary artery angiography （CAG）. Type 2 diabetese mellitus was diagnosed in 68 of CHD patients （T2DM group ） and the relationship between serum hsCRP level and coronary artery lesion was studied and compared to blood glucose normal group.Results： The CHD patients who had two or three branches of stenotic coronary vessels the serum level of hs-CRP was significantly higher in T2DM group.Conclusion：For CHD patients complicating T2DM,hsCRP is a reliable marker to prcdict the severity of coronary artery lesion.