青藤碱治疗类风湿关节炎临床观察

The clinical observition on Sinomenine for Rheumatoid Arthritis

目的观察青藤碱(SN)治疗类风湿关节炎(RA)的临床疗效。方法80例DAS28>3.2的RA患者随机分为治疗组正青风痛宁缓释片(SN)+甲氨喋呤(MTX)+柳氮磺氨吡啶(SASP)组40例,对照组:MTX+SASP组40例,比较治疗前后临床症状体征改善情况和实验室指标的变化。结果与治疗前比较,两组患者治疗后均有改善,而治疗组改善程度优于对照组。治疗组患者较快出现关节肿痛的缓解;治疗组的ACR70改善率明显优于对照组。结论SN治疗RA,兼具非甾体类消炎镇痛和DMARDs特点。

Objective To observe the effect of Sinomenine（SN） in treating rheumatoid arthritis（RA）. Methods 80 patients（DAS28〉3.2） were randomly divided into two groups, 40 in the treatment group： SN＋ methotrexate（MTX）＋ sulfasalazine（SASP） ,and 40 in the control group： MTX＋SASP. The changes of clinical symptoms and signs as well as laboratory critera. Results Clinical symptoms and signs were improved significantly after treatments in both groups,while the improvement of the treatment group was more obviously than that of the control group. Patients of treatment group had a faster resolution of joint pain and joint swollen. The ACR70 of the treatment group was higher than that of the control group. Conclusion SN has therapeutic effect for RA, worked as both nonsteroidal antiinflammatory drugs and disease-modifying antirheumatic drugs.