补肾法对颈动脉粥样硬化患者血清TNF-α、IL-6含量的影响　

Effects of Reinforcing Kidney Medicine on the Content of TNF-α and IL-6 in Serum of Patients with Carotid Atherosclerosis

目的观察补肾中药对颈动脉粥样硬化患者颈动脉粥样硬化程度及血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)含量的影响。方法将125例颈动脉粥样硬化患者随机分为两组,对照组口服辛伐他汀和肠溶阿司匹林,治疗组口服补肾汤;治疗3个月后比较两组患者颈动脉粥样硬化程度和血清TNF-α及IL-6含量变化。结果与治疗前比较,两组治疗后颈动脉平均斑块数量、颈动脉管腔直径、平均斑块面积和血清TNF-α、IL-6含量明显降低;与对照组比较,治疗组治疗后颈动脉平均斑块数量、平均斑块面积以及血清TNF-α含量均显著降低。结论补肾中药可显著调节颈动脉粥样硬化患者炎性细胞因子,通过抑制炎症损伤发挥抗颈动脉粥样硬化作用。

Objective： To observe the effect of reinforcing kidney medicine on the content of tumor.necrosis factor-α （TNF-α） and inerleukin-6 （IL-6） in serum of patients with the carotid atherosclerosis. Methods： 125 cases of patients with the carotid atherosclerosis were divided into two groups randomly. The treatment group was treated with reinforcing kidney medicine, and the control group was treated with simvastatin and enteric coated aspirin. The degree of atherosclerosis and the content of TNF-α and IL-6 in serum of patients were recorded before and 3 months after treatment. Results： Compared with previous treatment, the average quantity of plaque, the diameter of canalis caroticus, the average area of plaque and the content of TNF-α and IL-6 in serum were decreased obviously in two groups. The average quantity of plaque, the average area of plaque and the content of TNF-α in treatment group were decreased more significantly than control group. Conclusion： Reinforcing kidney medicine could regulate inflammation cytokine of the carotid atherosclerosis and inhibit carotid atherosclerosis by restraining inflammation damage.