摘要
中药药效物质辨识与中药质量控制一直是中药现代化研究的难点和热点问题。为了探寻中药药效物质与质量控制标准研究的重大突破,在回顾性研究和前瞻性分析的基础上,首次提出"基于成分敲除/敲入的中药药效物质辨识与质量控制模式"的研究设想,以期为又快又准地辨识中药药效关键组分,实现中药质量标准"关联药效,量而又准,可控可评"的愿景,提供具有原创性和实用性的研究思路和方法体系。
The patterns of efficient components recognition and quality control for Chinese materia medica (CMM) have been the difficult and hot topics for CMM modernization. To get a radical and significant breakthrough in the investigation on the efficient component recognition and quality control standard for CMM, a tentative idea about efficient component recognition and quality control pattern for CMM based on constituent knock-out/knock-in is initially proposed in this article on the foundation of retrospective and prospective analyses. And its main aim is to provide some creative and practical ideas and methods to recognize the key efficient components of CMM precisely and quickly, and to meet with the requirements that the quality control standards for CMM will be effectiveness-related, quantitative and accurate, controllable and assessable.
出处
《中草药》
CAS
CSCD
北大核心
2009年第9期1345-1348,1488,共5页
Chinese Traditional and Herbal Drugs
基金
国家"重大新药创制"科技重大专项课题(2009ZX09502022
2009ZX09502-003)
国家杰出青年科学基金项目(30625042)
国家"十一五"科技支撑计划课题(2006BAI08B03)
关键词
中药药效组分辨识
成分敲除/敲入
质量控制
efficient component recognition of Chinese materia medica
constituent knock-out/knock- in
quality control