细皱香薷叶的化学成分研究

Chemical constituents from leaves of Elsholtzia rugulosa

目的研究细皱香薷Elsholtzia rugulosa叶的化学成分。方法采用柱色谱法进行分离和纯化,通过波谱分析鉴定结构。结果从乙醇提取物中分离得到了12个化合物,鉴定结构分别为洋芹素-7-O-β-D-葡萄糖苷(Ⅰ)、木犀草素-7-O-β-D-葡萄糖苷(Ⅱ)、刺槐素-7-O-β-D-葡萄糖苷(Ⅲ)、木犀草素-7-O-(6″-乙酰基)-β-D-葡萄糖苷(Ⅳ)、苯甲醇-β-D-葡萄糖苷(Ⅴ)、prunasin(Ⅵ)、β-谷甾醇(Ⅶ)、桦木酸(Ⅷ)、2α-羟基乌苏酸(Ⅸ)、2α-羟基齐墩果酸(Ⅹ)、洋芹素(Ⅺ)和木犀草素(ⅩⅡ)。结论化合物Ⅰ、Ⅲ、Ⅳ、Ⅸ和Ⅹ为首次从该种植物中分离得到。

Objective To study the chemical constituents from the leaves of Elsholtzia rugulosa. Methods Compounds were isolated and purified by silica gel column and Sephadex LH-20 chromatography. Their chemical structures were identified by spectral data. Results Twelve compounds were isolated, purified, and identified as： apigenin-7-O-β-D-glueopyranoside （ Ⅰ ）, luteolin-7-O-β-D-glucopyranoside （ Ⅱ ）, acacetin-7-O-β-D-glucopyranoside （ Ⅲ ）, luteolin-7-O-（6＂-acetyl）-β-D-glucopyranoside （ Ⅳ ）, benzyl alcohol-β-D-glucopyranoside （ Ⅴ ）, prunasin （ Ⅵ ）, β-sitosterol （Ⅶ）, betulinic acid （Ⅷ）, corosolic acid （Ⅸ）, maslinic acid （ Ⅹ ）, apigenin （Ⅺ） and luteolin （ Ⅻ ）. Conclusion Compounds Ⅰ , Ⅲ, Ⅳ, Ⅸ, and Ⅹ are obtained from this plant for the first time.