伏立康唑治疗儿童血液病合并侵袭性真菌感染的疗效观察

Effect of Voriconazole in the treatment of childhood hematologic disease with invasive fungal infection

目的观察伏立康唑治疗儿童血液病合并侵袭性真菌感染(invasive fungal infection,IFI)的临床疗效和安全性。方法回顾性分析2007年8月至2009年4月18例血液病住院患儿合并IFI应用伏立康唑治疗的效果。结果伏立康唑治疗18例IFI患儿的总有效率为83.3%(15/18),3例患儿出现不良反应,经对症治疗后全部好转。结论伏立康唑可以有效治疗儿童血液病合并侵袭性真菌感染,不良反应少,多数能耐受,安全性高。

Objective To observe the therapeutic effect and side effect of Vorieonazole treating for invasive fungal infection in childhood hematologic disease. Methods Eighteen hospitalized hematologic disease patients complicated with invasive fungal infection were treated with Voriconazole,and the clinical data of the patients and the therapeutic effect were analyzed retrospectively. Results The clinical effective rate of Vorieonazole was 83.3%. Side effect was found in 3 patients and was cured after therapy. Conclusion Vorieunazole is an effective and safe treatment option for invasive fungal infection in patients with hematologic disease.