MRP在胰腺癌组织中的表达及其临床意义

The Clinicopathological Significance of MRP Expression in Pancreatic Carcinoma

目的:了解MRP蛋白在胰腺癌组织中的表达情况,并探讨其临床意义。方法:应用免疫组织化学法检测72例胰腺癌组织,10例正常胰腺组织中MRP蛋白的表达,并分析其与临床病理学特征及预后的关系。结果:MRP蛋白在胰腺癌组织中的阳性表达率为91.7%,明显高于其在正常胰腺组织中的表达(p<0.05)。胰腺癌组织中的MRP蛋白高表达与病理学分级低显著相关(p=0.031),亦与年龄有关(p<0.05),而与肿瘤生长部位、肿瘤大小、淋巴结有无转移、临床分期及神经有无浸润无显著相关性(p>0.05)。MRP蛋白高表达者的中位生存期明显长于低表达者(21.7个月vs11.1个月,p=0.040)。结论:胰腺癌组织中MRP蛋白的高表达与胰腺癌术后的预后好相关,检测胰腺癌中MRP蛋白的表达具有重要的临床意义。

Objective： To investigate the expression of MRP protein in pancreatic carcinoma and to determine its clinicopathological significance and the correlation between the expression of MRP and the clinical prognosis. Methods： In 72 cases of pancreatic carcinoma and 10 cases of normal pancreatic tissue samples, the expression of MRP was detected by immunohistochemical method. Results： The positive expression rate of MRP was 91.7%, which was remarkably higher than its in normal pancreatic tissue （p〈0.05）. The high expression of MRP was associated with lower pathological grade （p=0.031）, and it was also associated with age, but it was not associated with the location, size, lymph node metastasis, clinical stages and nerve invasion of the tumor. Patients with high intensity of MRP expression shower a significantly longer median survival time（21.7 month） than those with low intensity expression（11.1 month, p=0.040）. Conclusions： High levels of MRP expression are associated with favorable prognosis in pancreatic carcinoma. It is important to detect the level of MRP expression for pancreatic carcinoma after surgery.