拉莫三嗪单药治疗新诊断的癫痫患者两年保留率研究

Study on two years retention ratio of lamotrigine monotherapy to new diagnosed epilepsy patients

目的：研究拉莫三嗪单药治疗新诊断的癫痫患者两年保留率。方法：结合门诊随访和电话回访，复习138例新诊断的癫痫患者应用拉莫三嗪治疗两年的情况。结果：拉莫三嗪单药治疗新诊断的癫痫患者两年保留率为76．8％，其中女性患者为86．6％，高于男性患者的65％（P〈0．01）。20岁及以下的男性及女性患者较20岁以上患者保留率均低，相应男性为45．0％对74．4％和女性为75．7％对95．2％，男性及女性患者比较差异有显著意义P〈0．05。结论：拉莫三嗪单药治疗新诊断的癫痫患者的两年保留率较高。加强对男性及青少年患者的用药管理可提高保留率，增加治疗依从性。

Objective：To study the two years retention ratio of lamotrigine monotherapy to new diagnosed epilepsy patients. Methods： The application of lamotrigine monotherapy for two years in 138 patients with newly diagnosed epilepsy combined kvith clinic follow-up and a return visit by telephone. Resuits： The two years retention ratio of lamotrigine is 76.8% in monotherapy to newly diagnosed epilepsy patients. The retention ratio of lamotrigine in women patients（86.6%） was higher than that in patients （65.0%）（P〈0.01）. The two years retention ratio of lamotrigine in male and female patients under the age of 20 years old was lower than＇ that in patients above 20 （45.0 % vs74.4 %;75.7 % vs 95.2 % ） （ male and female patients P〈0. 05）. Conclusions： The retention ratio of lamotrigine is rather high in monotherapy to newly diagnosed epilepsy patients. The retention ratio and increasing compliance of lamotrigine can be raised by strengthing management of medicine in male and yaung patients.