急性脑梗死患者血浆Hcy、ET、NO、FA、VitB12水平变化的相关性研究

Clinical reserch of changes of Homocysteineand、Endothelin、Mononitrogen Monoxide 、Folic Acid and VitamineB12 in acute cerebral infarction

目的探讨急性脑梗死（ACI）患者血浆同型半胱氨酸（Hcy）、内皮素（ET）、一氧化氮（NO）、叶酸（FA）、维生B12（VitB12）变化及临床意义。方法应用DS30Hcy检测仪和Immulite仪器测定120例ACI患者（分为单纯ACI组60例、ACI并发症组60例）及对照组41例血浆ET、NO、FA、VitB12的水平。结果单纯ACI组和ACI并发症组血浆Hey、ET浓度明显高于对照组（P〈0．01），NO、FA、VitB12浓度低于对照组（P〈0．01）；单纯ACI组和ACI并发症组结果无显著性差异（P〉0．05）。结论血浆Hcy、ET、NO、FA、VitB12含量变化对于患者病情观察、预后判断具有重要意义，尤其是在患者中推行加服FA和VitB12等制剂，为ACI的预防和治疗开辟了新的途径。

Objective To investigate the clinical significations of changes of Homocysteineand, Endothelin, Mononitrogen Monoxide, Folic Acid and VitamineB12 in acute cerebral infarctions. Methods Plasma levels of Hcy.ET.NO.FA and VitB12 of 120 blood specimens collected form cerebral infarction patients（60cases have and have not complicatins respectively） and 41 specimens drew from healthy individuals which served as control group were detected by DS30Hcy and Immulite detecter. Results Levesl of Hcy.ET were higher in ACI group while NO.FA.VitB12 were lower than that in control group and the differeces were singnifficant （P 〈 0.01 ）. The differeces between patients had complications and free of coplications are no significant（P 〉 0. 05 ）. Conclusion Surveillance of plasma Hcy.ET.NO.FA and VitB12 values were essential to the observation of the state of illness and prognosis. The gnidence of clinical medication of prescription of Folic Acid and VitamineB12 to acute cerebral infarction patients.