D-二聚体、C反应蛋白、血沉与老年社区获得性肺炎严重程度的关系

The correlation of plasma D-dimer, CRP and ESR levels and severity in elderly patients with community-acquired pneumonia

目的探讨血浆D-二聚体、C反应蛋白（CRP）和血沉水平与老年社区获得性肺炎（CAP）严重程度的关系。方法收集130例老年CAP患者的临床资料，按不同的病情严重程度评分标准对患者进行分组，分别测定患者血浆D-二聚体、CRP、血沉水平，分析其在不同分组间的差异。结果不同肺炎严重度指数（PSI）分级间、不同CURB-65分组间D-二聚体、CRP水平比较差异均有统计学意义（P〈0．05），重症肺炎组D-二聚体、CRP水平均显著高于非重症肺炎组（P〈0．01）。血沉水平在以上不同分组间比较差异均无统计学意义。血浆D-二聚体与CRP水平显著相关（r=0．368，P〈0．01）。结论血浆CRP、D-二聚体水平与CAP的严重程度有一定的相关性，可作为判断病情的指标。

Objective To investigate the correlation of plasma D-dimer,C-reactive protein（CRP） and erythrocyte sedimentation rate （ESR）levels and severity in elderly patients with community-acquired pneumonia（CAP）. Methods 130 elderly patients with CAP were included and divided into different groups by different severity assessment criteria. Plasma D-dimer, CRP and ESR were measured. Compare their levels among different groups. Results The mean D-dimer, CRP levels were different significantly（P 〈0.05 ）among different pneumonia severity index （PSI）groups, different CURB-65 groups and between serious and non-serious pneumonia groups. But ESR was not different significantly among the different groups above. Conclusion Plasma D-dimer and CRP levels correlated with severity and it-could be useful for assessment of the severity of CAP in elderly patients.