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90例2型糖尿病应用甘精胰岛素的疗效和依从性观察

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摘要 目的观察90例2型糖尿病患者应用甘精胰岛素的疗效和依从性。方法选取90例空腹血糖(FPG)≥8mmol/L,糖化血红蛋白(HbA1c)≥7%的2型糖尿病患者,均以甘精胰岛素为基础治疗,配合餐前用药,经半个月的调整用药,使FPG≤7mmol/L,餐后2小时血糖(2hPG)≤9mmol/L,记录治疗3个月结束时胰岛素剂量、血糖改善、胰岛素依从性及低血糖情况。结果血糖达标时甘精胰岛素剂量0.19~0.23IU/kg,与基线FPG及2hPG、病程有一定的相关关系,治疗结束患者血糖明显改善,低血糖发生率低,单种口服药与甘精胰岛素配伍依从性高。结论甘精胰岛素的使用需兼顾疗效和依从性,提倡血糖失控的2型糖尿病患者在病程早期即开始采用甘精胰岛素治疗。
作者 叶曦 陈小雯
出处 《临床内科杂志》 CAS 2009年第10期704-706,共3页 Journal of Clinical Internal Medicine
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参考文献5

  • 1UKPDS study Group. Overview of six years therapy of type 2 diabetes a progressive disease (UKPDS16). Diabetes Care, 1995,44 : 1249-1258.
  • 2Stratton IM, Adler AZ, Ncil HAW, et al. Association of glycemia with macrovascular and microvaseular complications of type 2 diabetes;pro- Spective observational study( UKPDS35 ). BMJ,2000,321:405-412.
  • 3Matthaei S, Stumvoll M, Kellerer M, et al. Pathophysiology and pharmacological treatment of insulin resistance. Endocrine review,2000,21 : 585-618.
  • 4Riddle MC, Rosenstock J, Gerich J. et al. The treat-to-target trial : randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care,2003,26:3080-3086.
  • 5卜石,邢小燕,王娜,赵文惠,杨文英.长效胰岛素联合口服降糖药治疗2型糖尿病的疗效与安全性[J].中国循证医学杂志,2004,4(7):464-467. 被引量:157

二级参考文献8

  • 1Riddle MC,Rosenstock J,Gerich J.Insulin Glargine 4002 Study Investigators.The treat-to-target trial:randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients[J].Diabetes Care,2003; 26(11):3 080-3 086.
  • 2HOE 901/3002 Study Group.Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes[J].Diabetes Care,2000; 23(8):1 130-1 136
  • 3UKPDS Study Group.Stratton IM,Adler AI,Neil HAW,Matthews DR,Manley SE,Cull CA,Hadden D,Turner RC,Holman RR.Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes:prospective observational study (UKPDS 35) [J].BMJ,20
  • 4Wright A,Burden ACF,Paisey RB.Sulfonylurea Inadequacy:Efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the UK Prospective Diabetes Study (UKPDS 57)[J].Diabetes Care,2002; 25(2):330-336
  • 5Turner RC,Cull CA,Frighi V,Holman RR.Glycemic control with diet,sulfonylurea,metformin,or insulin in patients with type 2 diabetes mellitus:progressive requirement for multiple therapies (UKPDS 49).UK Prospective Diabetes Study (UKPDS) Group[J].JAMA,1999;
  • 6UKPDS Study Group.Klein R,Klein BE,Moss SE.Relation of glycemic control to diabetic microvascular complications indiabetes mellitus[J].Ann Intern Med,1996;124(1 Pt 2):90-96
  • 7UKPDS Study Group.Overview of six years' therapy of type 2 diabetes-a progressive disease (UKPDS 16)[J].Diabetes Care,1995; 44(11):1 249-1 258
  • 8Matthaei S.Endocrine review[M],21(6):585-618

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