摘要
以拓扑替康为模型药物,采用复乳法制备多囊脂质体,考察了分别以L-赖氨酸、聚乙烯醇和海藻酸钠为助乳化剂对脂质体粒径和包封率的影响。结果表明,三者均能作为助乳化剂得到多囊脂质体,但种类和用量对制品粒径和包封率均有显著影响。
Multivesicular liposomes (MVLs) loaded with topotecan were prepared by double emulsification The effects of L-lysine, polyvinyl alcohol and sodium alginate as co-emulsifier on the diameter and encapsulation efficiency of the multivesicular liposomes were investigated. The results showed that the MVLs could be obtained with the three compounds as co-emulsifier. The particle size and encapsulation efficiency were affected by the type and amount of co-emulsifier significantly.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2009年第10期758-760,765,共4页
Chinese Journal of Pharmaceuticals
基金
"重大新药创新"科技重大专项(2009ZX09310-003)