2007年合肥市5岁以下儿童病毒性乙型肝炎血清学标志监测结果分析

Survey on hepatitis B Serologic marker of children under 5 years old in Hefei,2007

目的了解合肥市5岁以下儿童病毒性乙型肝炎(乙肝)病毒(HBV)感染情况、保护性抗体阳性情况。方法采用分层抽样的方法,于2007年10月在合肥市7个县(区)采集不同年龄儿童血清标本,所有儿童按年龄分为0～岁、1～岁、2～岁、3～岁、4～岁5个年龄组,应用间接法ELISA检测乙肝5项指标,检验结果利用SPSS软件进行数据处理。结果共采集不同年龄人群血清标本851份,乙肝感染者23例,感染率2.70%,5个年龄组间感染率差异无统计学意义(χ2=7.65,P=0.09);HBV携带者1例,病毒携带率0.12%;有保护性抗体儿童463人,阳性率54.41%,各年龄组阳性率差异有统计学意义(χ2=130.79,P=0.00)。结论合肥市实施乙肝疫苗接种15年来乙肝综合防制措施成效显著,有效控制了儿童乙肝的流行。

Objective To find out the HBV infection status and antibody level of the children under five years old in Hefei,provide the scientific basis for the effective prevention of hepatitis B.Methods By stratified sampling,blood samples were taken from the children aged 0,1,2,3,4 years old in 7 counties in Hefei in October,2007,the detection of samples was performed by using ELISA and the results were analyzed by using SPSS.Results Among 851 samples taken from the children with different ages,23 were positive for HBV,the infection rate was 2.70%.The differences on infection rate for different aged children had no statistical significance（P〉0.05）.One HBV carrier was found（0.12%）.The antibody to HBV was detected in 463 children（54.41%）,The differences on antibody positive rate for different aged children had statistical significance（P〈0.05）.Conclusion The prevention and control of hepatitis B in Hefei has made great achievement since the implementation of hepatitis B vaccination,so the epidemic of hepatitis B children was controlled effectively.