百螺敌对泥鳅的遗传毒性研究

Genetic Toxicity of Triphenyltin Acetate to Oriental Weatherfish Misgurnus angullicaudatus

采用急性毒性试验和红细胞微核测试的亚毒性试验研究了百螺敌(三苯基乙酸锡)对泥鳅急性及亚毒性的影响。试验结果表明,在急性毒性试验中,百螺敌在24、48、72、96 h半致死质量浓度(LC50)分别为1.425、1.215、0.938、0.800 mg/L,安全质量浓度为0.265 mg/L。百螺敌的亚毒性试验中,微核率和核异常率随着百螺敌质量浓度的加大和染毒时间的延长而增高,出现正向剂量—效应关系;达到最高值后开始下降,核异常率在百螺敌质量浓度为1.4 mg/L时,出现峰值;而微核率高峰出现在1.1 mg/L处。且核异常率远大于微核率。诱变的微核率和核异常率与对照相比达到显著或极显著差异水平。说明百螺敌对水生生物具有较强的诱变效应,应合理使用。

The acute and chronic toxicity of triphenyhin acetate to oriental weatherfish Misgurnus angullicaudatus was studied by toxicity tests and micronuclei tests of erythrocytes. The results showed that the median lethal concentrations （LC50） for 24, 48, 72, and 96 h of triphenyltin acetate were 1. 425 mg/L, 1. 215 mg/L, 0. 938 mg/L,a 0. 800 mg/L, respectively; and the safe concentration of 0. 265 mg/L. The incidence of micronuclei and nuclear anomalies appeared a positive dosage effect relationship in the low concentration of triphenyltin acetate, and then the incidence of micronuclei and nuclear anomalies appeared a negative dosage effect relationship at 1. 4 mg/L and 1. 1 mg/L in chronic toxicity tests. There were much higher nuclear anomalies than incidence of micronuclei, indicating that triphenyhin acetate had strong inductive effects on aquatic animals.