静脉输液微粒引起小鼠产生炎症反应

Particulate in Infusion Fluid Induce Mice Produce Inflammatory Reaction

目的探讨静脉输液微粒对人体的危害性,以及评价可溶性细胞间黏附分子-1(sICAM-1)和白介素-6在实验中的意义。方法将120只实验用昆明小白鼠分为4组,每组30只,分别静脉注射不同浓度的直径为4～5微米的非代谢物质,清洁饲养6个月后宰杀作病理切片及血液生化检验。结果高倍显微镜下发现实验动物血管内皮细胞(EC)损伤明显,同期生化检验结果发现可溶性细胞间黏附分子-1(sICAM-1)含量明显大于对照组(P<0.01);白介素-6(IL-6)的含量也明显大于对照组(0.02<P<0.05)。结论静脉用药中微粒污染存在明显危害,可导致严重的炎症反应。

Objective To study the danger of the non - metabolic material on circulation system by administering through vein except the pharmaceuticals itself. Methods Total 120 Kunming species mouse were selected and randomly divided into 4 groups. Each group has 30 cases. The non - metabolic material with diameter 4 - 5 micron at different concentration were administered to the four group, then these mouse were killed for pathological section and blood biochemical analysis after six months cleanly raising. Results The mouse＇ s blood vessel endothelial cell （EC） was remarkably endangered, At the same time, the number of serum soluble intercellular adhesion molecule - 1 （ sICAM - 1 ） content is greater than that of control group by biochemical analysis （P 〈0. 01 ）. The number of Interleukin - 6 （ IL - 6 ） is greater than that of control group （0.02 〈 P 〈 0. 05 ）. Conclusion It is clear that the endanger on circulation system by non - metabolic material are existed, and can cause a serious inflammatory reaction.