产妇血清乳汁HBV标志物含量、HBV—DNA载量相关性与母乳喂养安全性的研究

Discussing the Connection between the Different Content of the Hepatitis B Viruses （HBV） Marker in the Serum and Latex of the Puerperal Who Carried HBV and the Security of Breast Feeding

目的探讨HBV携带产妇的血清、乳汁中HBV标志物不同含量与实施母乳喂养安全性的关系。方法应用荧光定量聚合酶链反应和时间分辨免疫测定技术对HBV携带产妇的血清、乳汁进行HBV—DNA定量和HBV—M检测。结果HBV携带产妇血清、乳汁中HBV—DNA阳性率、载量与HBV—M状态和病毒含量具有相关性。结论HBeAg定量结果〉2．83NCU／ml的新生儿即使给予主、被动联合免疫，也应谨慎考虑母乳喂养问题；HBeAg定量结果〈2．83NCU／ml和HBeAg阴性产妇的婴儿采取适当的免疫措施后母乳喂养是可行的。

Objective Discussing the connection between the different content of the hepatitis B viruses （HBV） marker in the serum and latex of the puerperal who carried HBV and the security of breast feeding. Methods Tested the HBV-DNA and HBVM in the serum and latex of the puerperal that carried HBV by fluorescence quantitative PCR and time-resolved fluorescent immunoassay. Results There were correlation between the positive rate and capacity of the HBV-DNA and the status of the HBV-M in the serum and latex of the puerperal who carried HBV. Conclusion The newborns whose quantitative examination result of HBeAg was greater than 2.83 NCU/ml,even they were gave active and passive combined immunization,should be accounted carefully about the breast feeding;but the newborns whose quantitative examination result of HBeAg was less than 2.83 NCU/ml ,the HBeAg of the puerperal were negative and they were gave appropriate immune measure could give breast feeding.