MSCT灌注成像诊断乳腺癌

MSCT perfusion imaging in diagnosis of breast cancer

目的观察乳腺癌、乳腺良性实质肿瘤及乳腺癌旁正常腺体组织的MSCT灌注成像特征。方法对38例乳腺实质肿瘤患者行灌注扫描。比较乳腺癌、乳腺良性实质肿瘤和乳腺癌旁正常腺体组织的TDC和MIP、AV、BF、BV、TTS、TTP、PS和PBV等灌注参数,采用χ2检验、独立样本t检验进行统计学处理。结果癌旁正常乳腺腺体组织TDC均为平坦型,流出型和平台型中分别有76.47%、71.43%为乳腺癌,而流入型85.72%为良性实质肿瘤。乳腺癌的BF、BV、PS、PBV均高于良性实质肿瘤及癌旁正常乳腺腺体组织。最大径2.0cm以上的乳腺癌和乳腺良性实质肿瘤的中心带与边缘带瘤组织MIP、AV、BF、BV、PBV差异有统计学意义,乳腺癌中心带低于边缘带,良性实质肿瘤反之。结论MSCTPI对乳腺癌的诊断、鉴别诊断具有重要价值。

Objective To study the characteristics of MSCT perfusion imaging（MSCTPI） in breast cancer,breast benign tumors and corresponding non-tumor normal tissues.Methods MSCTPI was performed on 38 patients with breast tumors.Chi-square tests and independent samples t-test were applied to compare the TDC types and perfusion parameters＇ values of breast cancer,breast benign tumors and corresponding non-tumor breast tissues.Perfusion parameters included maximum intensity projection（MIP）,average value（AV）,blood flow（BF）,blood volume（BV）,time to start（TTS）,time to peak（TTP）,permeability surface（PS） and Patlak blood volume（PBV）.Results TDC of corresponding non-tumor breast tissues were all flat-type.Among outflow-type and platform-type TDC,76.47% and 71.43% were breast cancer,while 85.72% breast tumors with inflow-type TDC were benign.The means of BF,BV,PS and PBV in breast cancer were higher than those of benign breast tumor and corresponding non-tumor normal tissues.The means of MIP,AV,BF,BV and PBV of center zone were lower than those of boundary zone in breast cancer focus ≥2.0 cm,while the means of MIP,AV,BF,BV and PBV of center zoon were higher than those of boundary zone in benign breast tumors.Conclusion Breast cancer has special MSCTPI characteristics that being helpful to the diagnosis and differential diagnosis of breast cancer.