乙型肝炎病毒感染者血清中sFas,sFaL水平测定及其意义

Detection and significant of sFas and sFasL value in the serum of patients infected with hepatitis B virus

[目的]检测乙型肝炎病毒感染者血清中可溶性Fas(sFas)及可溶性Fasligand(sFasL)水平,分析其与肝细胞炎症程度的关系.[方法]选择行肝穿刺患者60例(男性为46例,女性为14例),其中住院的慢性乙型肝炎患者为30例,门诊就诊乙型肝炎病毒携带者为30例,另选择正常人30例(男性为23例,女性为7例)列入对照组.给所有对象进行肝功能检测,对乙型肝炎及携带者进行肝穿刺,分型.[结果]慢性乙型肝炎组患者血清sFas值明显高于携带者组及对照组,血清sFasL值明显低于携带者组.慢性乙型肝炎组门静脉周围、肝小叶及门静脉炎症程度在中度以上患者血清中sFas值较对照组明显增高,肝纤维化轻、中、重度患者血清中sFas值较对照组亦均明显增高.[结论]血清sFas值的变化可反映肝组织的炎症程度.

OBJECTIVE To detect serum solubility Fas （sFas） and solubility Fas ligand （sFasL） in the serum of chronic hepatitis B （CHB）, and to analyze the relation with inflammation of hepatocyte. METHODS 60 patients （46 of male, 14 of female） of CHB, including 30 of CHB in inpatients and 30 of CHB in outpatients performed liver biopsy were selected, and 30 cases （23 of male, 7 of female） of normal individual were selected as control group. All subjects were detected the liver function by automatic biochemistry analyzer, and the patients with hepatitis B and virus carrier were performed liver biopsy and classified. RESULTS The serum sFas values were significantly higher in CHB group than in virus carriers and normal groups, and serum sFasL values were significantly lower in CHB group than in virus carrier group. The serum sFas values over middle degree of inflammation of surrounding portal vein, hepatic lobules and portal vein were significantly higher in CHB group than in control group, and serum sFas values in light, middle and severe liver fibrosis were all significantly higher than that in control group, too. CONCLUSION The changes of serum sFas value in patients infected with hepatitis B virus can reflect the degree of hepatitis.