术前不同化疗模式对肾母细胞瘤VEGF表达的影响及其与预后的关系

Prognostic Effect of VEGF Expression after Different Methods of Preoperative Chemotherapy in Nephroblastoma

目的探讨儿童肾母细胞瘤(WT)术前不同化疗模式对血管内皮生长因子(VEGF)表达的影响及其与预后的关系。方法37例WT患儿,按术前化疗方式分为3组,12例术前全身化疗(A组);12例术前介入栓塞化疗(B组);13例未进行术前化疗(C组)。采用免疫组化法检测肿瘤VEGF的表达,通过单因素和多因素生存分析了解肾母细胞瘤患者在不同术前化疗模式下VEGF的表达及其对预后的影响。结果A组、B组肿瘤细胞VEGF表达较C组降低(P<0.05),B组VEGF表达较A组高(P<0.05),单因素分析结果显示化疗后WT肿瘤细胞VEGF的表达与预后相关(P<0.05),但在Cox模型多因素分析其并不是独立影响因素(P>0.05)。结论术前化疗后WT肿瘤细胞VEGF表达降低,化疗后VEGF的表达是影响预后的因素之一,但不是决定因素。

Objective To study the expression of VEGF within Wilm tumor in different preoperative chemotherapy patterns aad prognostic effect.Methods 37 eases of Wilm tumor were observed,12 cases were treated with preoperative chemotherapy,12 cases were treated with transcatheter arterial chemoembolization （TACE） in pre-operafion and 13 cases had no preoperative chemotherapy. The expression of VEGF was detected by immunohistochemistry after tumor resection and the relationship of VEGF and prognosis was elucidated by using single and multiple survival analysis. Results The expression of VEGF in A and B groups were lower than C group （P 〈 0.05）, and that of group A is higher than group B （P 〈 0. 05）. In the single survival analysis VEGF was related with prognosis （P 〈 0. 05） while it was not a independent factor in the multiple analysis （P 〉0.05）. Conclusion VEGF of Wilm tumor was decreased after the preoperative chemotherapy and correlated with prognosis ,but which is not definitive factors.