心脏房间隔缺损/卵圆孔未闭封堵器——从不降解到可降解

ASD/PFO Devices:from Non-degradable to Degradable

房间隔缺损和卵圆孔未闭是临床常见的2种先天性心脏发育畸形。封堵器作为介入治疗房间隔缺损和卵圆孔未闭的装置,其作用是对房间隔上面未能闭合的孔进行封闭。可调节与可吸收是新型封堵器的2个发展方向。介绍了国内外封堵器装置的种类、特点以及临床实验情况,结合现有一些生物可降解的高分子材料,分析了可生物吸收、可生物降解封堵器的研究意义和可行性。

Atrial septal defect （ASD） and patent foramen ovale （PFO） are two common types of congenital heart malformations. Occluder, as transcatheter closure devi ce, has been designed to close congenital heart defects. Various types of occluder are currently available commercially or within clinical trials. Adjustable and biodegradable are two development directions of occluder. Several types of occluder at home and abroad, including their shapes, characteristics, as well as clinical trials are introduced. In combination of some biodegradable polymer materials, the possibility and the significance of the biodegradable devices are discussed.