无锡市女性乳腺癌危险因素病例对照研究

Related risk factors of breast cancer in female of Wuxi city:a case-control study

目的研究乳腺癌危险因素,探讨不同因素间的交互作用对乳腺癌发生的影响。方法运用病例-对照研究,以Logistic回归分析危险因素及可能存在的交互作用。结果初潮早、首或末次怀孕年龄晚、痛经是乳腺癌的危险因素,调整OR（95%CI）分别为：1.79（1.26－2.55）,1.56（1.10－2.20）,1.49（1.04－2.15）,1.88（1.22－2.90）。哺乳和生育可能降低乳腺癌发生风险。初潮早和首（末）次怀孕年龄晚、不饮茶和初潮早、首（末）次怀孕年龄晚、乳腺癌家族史间均具有联合作用（Ptrend〈0.01）。初潮早和不饮茶以及首次怀孕晚和不饮茶间具有显著的相乘交互作用（Pint值分别为0.029和0.000）结论初潮早和首（末）次怀孕年龄晚是乳腺癌的危险因素,饮茶可显著降低发病风险,无饮茶史合并初潮早和首（末）次怀孕年龄晚显著增加乳腺癌发病风险。

Objective To investigate the risk factors related to breast cancer and the potential interaction between the factors. Methods A case-control study with 223 newly diagnosed female breast cancer patients and 322 healthy controls was conducted and unconditional Logistic regression was used to evaluate the risk. Results Early age at menarche（ EAM）, late age at first and last pregnancy （LAFP and LALP）, dysmenorrheal could increase breast cancer risk with adjusted ORs （95% CI） of 1.79 （ 1.26 - 2. 55 ）, 1.56 （ 1.10 - 2. 20 ）, 1.49 （ 1.04 - 2.15 ）, 1.88 （ 1.22 - 2.90 ）, respectively. Lactation could decrease breast cancer risk. There were combined effects between EAM and LAFP, EAM and LALP, EAM and not drinking tea,LAFP and not drinking tea, LALP and not drinking tea, family history of breast cancer and not drinking tea （Ptrend 〈0. 01 ）. There were multiple interaction between EAM and not drinking tea. LAFP and not drinking tea（Pint =0. 029 and 0. 000）. Conclusion EAM,LAFP and LALP were risk factors of breast cancer,whereas,drinking tea may decrease the risk of breast cancer. Not drinking tea combined with EAM,LAFP,LALP could increase breast cancer risk greatly.