摘要
以9周龄雄性原发性高血压大鼠(SHR)为受试动物,研究螺旋藻蛋白及其水解产物对SHR血压的影响。将螺旋藻蛋白、胃蛋白酶水解产物、胰蛋白酶水解产物及复合酶水解产物以高中低三个剂量(5、1、0.2g/kg)分别灌胃SHR,以生理盐水为对照,用鼠尾无创动脉测量仪测定灌胃0、1、2、3、4、5、6、7、8h后SHR的血压变化情况。结果显示:胃蛋白酶水解产物、胰蛋白酶水解产物及复合酶水解产物在0～8h内对SHR的血压升高具有明显的抑制作用,其中高剂量组复合酶水解产物在0～6h内降压效果最佳,血压维持在较低水平的时间最长,达到了6h,血压值下降了(23.1±1.0)mmHg(1mmHg=133.322Pa)。
In order to investigate the effects of Spirulina protein and its hydrolysates on blood pressure, 9-week-old male spontaneously hypertensive rats （SHR） were used as experimental subjects, which were orally administered with Spirulina protein, its hydrolysates prepared with pepsin, trypsin and complex enzyme at doses of 5, 1 and 0.2 g/kg, respectively, or saline. Subsequently, systolic blood pressure of SHR was measured using a ZH-HX-Z programmed electro-sphygmomanom- eter at a fixed time interval （0, 1, 2, 3, 4, 5, 6, 7 and 8 h） post-administration. Results showed that all hydrolysates had significant inhibition on blood pressure of SHR and compound enzyme hydrolysates had the strongest effect on antihypertension at dose of 5 g/kg during 0 -- 6 h. Moreover, systolic blood pressure was decreased up to （23.1 ± 1.0） mmHg at this dosage.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2009年第19期276-278,共3页
Food Science
基金
天津市科技支撑重点项目(06YFGCNC04200)
