摘要
目的:评价新化合物多穗柯根皮苷水杨酸酯的生物活性。方法:用根皮苷水杨酸酯灌胃处理糖尿病小鼠模型,以二甲双胍为阳性对照,检测空腹、餐后血糖水平和糖耐量,并检测其清除2,2'-diphenyl-1-picrylhydrazyl(DPPH)自由基的能力。结果:根皮苷水杨酸酯清除DPPH.的IC50为113mg/L,明显低于根皮苷的IC50(163mg/L);根皮苷水杨酸酯在控制糖尿病小鼠空腹、餐后血糖水平和糖耐量方面都比根皮苷有更好的效果。结论:经水杨酸酯化修饰后的根皮苷的降血糖效果和抗氧化性得到了改善。
Objective： To evaluate bioactivity of the new compound, phloridzin-6＂-O-salicylate. Methods： Diabetic mice were orally administered with phloddzin-6＂-O-salicylate and methformin was used as a positive control. Fasting and non-fasting blood glucose levels, glucose tolerance, and 2,2＇ -diphenyl-l-picrylhydrazyl free radical （DPPH .） scavenging capability were detected. Results： IC50 of phloridzin-6＂-O-salicylate for DPPH. scavenging was 113 rag/L, which was significantly lower than that of phloridzin （IC50 = 163 mg/L）. Moreover, phioridzin-6＂-O-salicylate had better effects on the control of fasting and non-fasting blood glucose levels and glucose tolerance in diabetic mice than phloridzin. Conclusion： Hypoglycemic and antioxidant activities of phloridzin modified by salicvlate estedfication were significantlv improved.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2009年第19期279-282,共4页
Food Science
基金
广东省自然科学基金项目(8152800001000023)
