苦瓜皂甙对去卵巢和高血脂症大鼠血脂的影响

Effects of Momordica charantia L. Saponins on Blood Lipids in Rats

分别以去卵巢和高血脂症大鼠为研究对象,以大鼠血清血脂参数为指标,研究连续给予苦瓜皂甙65、130、260mg/kg·d12周和20d后对去卵巢和高血脂症大鼠血脂的影响。结果表明:苦瓜皂甙130mg/kg·d和260mg/kg·d组,可明显降低去卵巢大鼠血清胆固醇(TC)和低密度脂蛋白-胆固醇(LDL-C)水平,纠正脂代谢失衡;可明显抑制高脂引发的血清TC、甘油三酯(TG)、LDL-C/HDL-C比值的升高,且具有剂量依赖趋势,对高血脂症大鼠具有降血脂作用。

In order to understand effects ofMomordica charantia L. saponins on blood lipids, the change of blood lipid profile in ovariectomized and hyperlipoidemia rats was determined after treated with Momordica charantia L. saponins at doses of 65, 130 and 260 mg/kg/day for 12weeks and 20 days, respectively. Results indicated that Momordica charantia L, saponins at doses of 130 and 260 mg/kg-d significantly decreased total cholesterol （TC） and low-density lipoprotein-cholesterol （LDL-C） in serum of ovariectomized rats. Meanwhile, Momordica charantia L. saponins at dose of 130 and 260 mg/kg also obviously inhibited the increase of TC, LDL-C and triglyceride （TG） in a dose-dependent mode. Therefore, Momordica charantia L. saponins reveals a significant reduction effect on blood lipids in rats with hyperlipoidemia.