SLE患者血清B-ALP、PINP、NTX、CTX水平的研究

The research of the serum level of B-ALP、PINP、NTX、 CTX in patients with systemic lupus erythematosus

目的B-ALP、PINP、NTX、CTX是骨形成和代谢的指标,为了解系统性红斑狼疮(SLE)患者骨代谢状况,对系统性红斑狼疮(SLE)患者血清的B-ALP、PINP、NTX、CTX进行了测定。方法测定42例SLE患者及30例正常对照者血清的B-ALP、PINP、NTX、CTX水平。结果SLE患者血清B-ALP(5.03±1.22)μg/L、PINP(30.18±5.14)μg/L较正常对照组的B-ALP(7.85±1.30)μg/L、PINP(45.12±4.95)μg/L明显下降(P<0.05)。SLE患者血清NTX(5.12±1.08)nmBCE/L、CTX(0.26±0.07)μg/L较正常对照组的NTX(2.01±0.95)nmBCE/L、CTX(0.15±0.05)μg/L明显上升(P<0.05)。结论SLE患者存在骨形成障碍,骨吸收率增高。

Objective To understand the bone metabolism in the patients with systemic lupus erythematosus （SLE）by determining the serum level of B-ALP,PINP,NTX, CTX. Methods Forty two patients with SLE and 30 matched normal controls were studied. The serum level of B-ALP,PINP,NTX, CTX were measured. Results The serum level of B-ALP（ （5.03 ± 1.22） μg/L,PINP（30. 18 ±5.14）μg/L in SLE patients were significantly lower than that of the normal subjects （B-ALP 7. 85 ± 1.30）μg/L; （PINP45. 12 ±4. 95）μg/ L （P 〈0.05 ）. The serum level of NTX（ 5. 12 ± 1.08 nmBCE/L）, CTX （0. 26 ± 0. 07 ）μg/Lin SLE patients were significantly higher than that of the normal subjects （ NTX 2. 01 ± 0. 95 nmBCE/L）, （ CTX 0. 15 ± 0. 05 ） μg/L （ P 〈 0. 05 ）. Conclusion Abnormal bone formation and decreased bone turn over exist in SLE.