具有抗炎、抗过敏活性磷脂酶抑制剂的研究进展

Recent Advances in Phospholipase Inhibitors

磷脂酶参与细胞跨膜信息传递，磷脂酶Ａ２还是机体炎症、过敏介质产生的关键酶。因此，磷脂酶抑制剂的合成研究对研究细胞表达某种功能的信息传递机制及与磷脂酶Ａ２激活相关的疾病治疗机制和药物研究具有重要意义。本文主要综述了近期有关磷脂酶Ａ２抑制剂的合成、结构、抑效性能、构效关系及应用前景等，对磷脂酶Ｃ和磷脂酶Ｄ的抑制剂作了简要介绍。

Phospholipase A2,C,D are involved in the pathways of cell transmembrane signal transduction,and phospholipase A2(PLA2) is also a critical enzyme which catalyzes the specific hydrolysis of membrane phospholipids and causes the release of inflammatory and allergic mediators.The studies on phospholipase inhibitors are of significance in investigating the mechanism of the signal transduction of cell functional expression and the mechanism of some diseases related with PLA2 activation,and also in the development of some antiinflammatory and antiallergic drugs.A brief review on phospholipase inhibitors including their structures,properties, structureeffect relationship and application prospects is given.