爱活尿通对精液中部分凝血因子及液化时间影响的初步研究

A primary study on the changes of blood coagulation factors in semen and liquefaction time of semen under Eviprostat treatment

目的探讨爱活尿通对人类精液液化时间延长者的治疗效果,同步检测治疗前后精液中凝血因子的变化。方法 46例精液液化时间延长者口服爱活尿通为治疗组,2周后复查精液液化时间,同时检测治疗前后精液中组织因子(TF)、凝血因子Ⅶa(F Ⅶa)及凝血因子ⅧAg(F Ⅷ Ag)含量。45例精液常规正常者作为对照组。结果经治疗,32例液化时间<30 min,占70%,12例液化时间在30至60 min之间,占26%,2例液化时间仍大于60 min,占4%,较治疗前液化时间缩短,且精子活力提高,差异有显著性(P<0.05);治疗后精液中TF、F Ⅶ a及FⅧ Ag含量降低(P<0.05),与对照组相比无统计学意义(P>0.05)。结论爱活尿通对精液液化时间延长者有一定疗效;对影响精液液化的凝血因子水平可能具有改善作用。

Objective To investigate the clinical effect of Eviprostat for the treatment of patients with semen delayed liquefaction, and analyze the changes of blood coagulation factor in semen before and after treatment. Methods All 46 patients with semen delayed liquefaction were treated with Eviprostat for two weeks. The liquefaction time of semen and the content of coagulation factors（TF, F Ⅶ a and F Ⅷ Ag） were detected respectively before and after treatment. Other 45 normal semen samples were set as the control. Results After treatment, semen liquefaction limes of 32 patients were shorter than 30 minute （70%）, 12 patients over 30 minutes（26%）, and other 2 patients over 60 minutes （4%）. There were significant differences in liquefaction time and the sperm viability before and after treatment（P〈0.05）; The content of TF, F Ⅶ a and F Ⅷ Ag in semen were significantly decreased after treatment（P〈0.05）, but no significant difference was found in the level of TF, F Ⅶa and F Ⅷ Ag compared with that of the control （P〉0.05）. Conclusion Eviprostat was effective in treatment of the patients with semen delayed liquefaction by changing the content of TF, F Ⅶ a and F Ⅷ Ag in semen.