摘要
用低价钛试剂(TiCl_4-Zn)与α,α-(4-氯苯基)(二氰甲基)甲基苯基酮反应合成了非对映消旋体(3R,SS;3S,5R)和(3R,5R;3S,5S)2-氨基-3-羟基-3-苯基-5-对氯苯基环戊烯-1-腈。并用X射线衍射分析确定了这两个非对映异构体的构型。
The diastereomeric racemates(3R,5S;3S,5R) and (3R,5R;3S,5S) 2- amino - 3 -hydroxy - 3 - phenyl - 5 - (4' - chlorophenyl) cyclopentene - 1 - carbonitriles were synthesized by reaction of low - valent titanium reagent (TiCl4 - Zn) with a, a - (4 - chlorophenyl) (dicyanomethyl) methyl phenyl ketone. Their configurations were determined by X - ray analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1998年第5期456-461,共6页
Chinese Journal of Organic Chemistry
基金
江苏省青年科技基金
关键词
低价
钛
氨基
羟基环戊烯
腈
合成
晶体
拆分
low - valent titanium reagent, 2 - amino - 3 - hydroxycyclopentene - 1 - carbonitrile, synthesis,crystal structure,configuration
