代谢综合征的中医证素与腹围、胰岛素抵抗的相关性研究

Explore Relation of TCM Syndrome Element and Waist Circumference with Insulin Resistance in Metabolic Syndrome

目的:探讨代谢综合征的中医证素与腰围、胰岛素抵抗的关系。方法:采集233例代谢综合征患者的四诊资料,应用"证素辨证"方法,同时检测腰围、血糖和胰岛素水平,计算胰岛素抵抗指数。结果:①代谢综合征基本证素为:气虚、血虚、阴虚、阳虚、津亏、痰、血瘀、湿、热、气滞、心、肝、脾、肺、肾。②影响腰围的因素只有中医证素痰,标准回归系数为0.322(P<0.01),不同男女性别腰围在痰的积分在≥100分组较<100分组有显著性差异。③影响HOMA-IR的因素只有中医证素痰和脾,标准回归系数分别为0.445(P<0.01)、0.162(P<0.01),不同痰的积分组间有显著性差异。结论:由此推断腰围可以作为痰证辨证的重要依据之一,同时可能说明HOMA-IR与中医证素痰在代谢综合征病理机制中存在着基本共性。

Objectlve：To explore the relationships of TCM syndrome element and waist circumference with insulin resistance in metabolic syndrome （MS）. Methods： Choosing metabolic syndrome patients 233 cases, combing syndrome differentiation by syndrome element, analysing the diagnosis informations by statistic process, detecting waist circumference,blood glucose and insulin, Calculating HOMA-IR. Results： ①the common elements of syndrome of metabolic syndrome ： Qi deficiency, blood deficiency, yin deficiency, insufficiency of yang, Lack of Jin, retention of dampness, blood stasis,dampness,shotness,Qi stagnation, heart, liver, spleen, pulmonary and kidney. ②Stepwise analysis showed that waist circumference level was only associated positively with retention of dampness. Standard regression coefficient is 0. 322（ P 〈 0.01 ）. Different gender of waist circumference in retention of dampness points were significantly different, in the group of more than 100 points than the group of Less than 100 points. ③Stepwise analysis showed that HOMA-IR was associated positively with retention of dampness and spleen. Standard regression coefficient are 0.445（ P 〈 0.01 ） anol 0.162（ P 〈 0.01 ） . The different group of retention of dampness points were significantly different. Conclusions ： It could be Inferred that waist circumference can be used as one of objective indexes to retention of dampness. It may indicated that HOMA-IR and retention of dampness in the pathogenesis of metabolic syndrome were basic common.