锌氨基酸螯合物的抑菌活性研究

Antibacterial Activities of Four Zinc-amino Acid Chelates

为研究锌氨基酸螯合物的抑菌活性,用EDTA络合滴定法测定四种锌氨基酸螯合物——甘氨酸锌、苏氨酸锌、蛋氨酸锌和赖氨酸锌的锌含量,并利用红外光谱对其进行表征。最后采用琼脂扩散法和微量肉汤稀释法检测四种锌氨基酸螯合物、硫酸锌、庆大霉素对大肠杆菌、枯草芽孢杆菌和金黄色葡萄球菌的抑菌效果。发现锌氨基酸螯合物有一定的抑菌活性,其抑菌效果与锌离子含量有关。

Four zinc-amino acid chelates, including zinc-glycinate, zinc-threoninate, zinc-methioninate and zinc-lysinate chelates were determined by EDTA titration for their zinc contents and characterized by infrared spectroscopy and their antibacterial activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus were assayed by agar diffusion method and broth dilution methods and compared with those of zinc sulfate and gentamycin. The results showed that all these zincamino acid chelates have a certain antibacterial activity which is associated with zinc content.