氨溴索注射剂对多索茶碱在大鼠体内药动学的影响

Effect of ambroxol injection on pharmacokinetics of doxophylline in rabbits

目的研究氨溴索对多索茶碱(DP)在大鼠体内的药动学参数的影响。方法采用HPLC法测定16只大鼠单独给予DP和合并盐酸氨溴索给药后DP以及其代谢产物茶碱(TP)的血药浓度,用DAS药动学软件对DP血药浓度-时间数据采用非房室模型分析,求得DP在大鼠体内主要的药动学参数,并对其进行统计分析。结果2组大鼠DP药动学参数t21、AUC0→t、MRT0→7h、Vz/F、CL/F、tmax、ρmax差异均无统计学意义(Ρ>0.05)。但氨溴索与DP合并使用时,DP代谢产物TP的AUC0-7h2组差异具有统计学意义(Ρ<0.05),合用组提高了38.77%。结论氨溴索对DP在大鼠体内动力学过程无影响,但有减缓DP的代谢产物TP代谢的趋势,两药同时使用时,应注意监测TP的血药浓度。

A/M To study the effect of ambroxol injection on pharmacokinetics of doxophylline in rats. METHODS A total of 16 rats were divided into two groups：one was administrated with doxophylline individually and another with the combination of doxophylline and ambroxol. Concentrations of doxophylline and its metabolite theophylline in plasma were determined by HPLC. The plasma concentration-time data of doxophylline were analyzed by DAS program according to no-compamnent model. The main pharmacokinetic parameters of doxophylline were obtained and compared with SPSS software between two groups. RESULTS No significant differences were found on the main phannacokinetie parameters such as t1/2, AUC0→t, MRT0→7 h, Vz/F,CL/F, tmax and ρmax, of doxophylline between two groups（ P 〉 0.05）. But the AUC of doxophylline＇ s, metabolite theophylline after co-administration showed significant difference（ P 〈 0.05）and it was increased by 38.77 %. CONCLUSION There is no effect of ambroxol on phannacokinetics of doxophylline in rats. But ambroxol can slowed down the metabolism of theophylline. The concentration of theophylline in plasma should be monitored when doxophylline and ambroxol are co-administered.