摘要
利用雪松二醇苯基硼酸酯进行不对称合成反应,制得标题化合物并测定结构.其晶体属正交晶系,空间群为P212121。结晶学多数为:a=5.728(3),b=8.543(3),c=41.267(7)A,V=2019.7A3;Z=4,Dc=1.23g/cm3,μ(CuKa)=17.7cm-1,R=0.0072,Rw=20.0077.独立可观察反射点数(I>3σ(I))为739个。由晶体结构图可看出,由于雪松二醇基团的空间住阻效应,反应产物有很高的非对称选择性。
Asymmetric synthesis of cedranediol phenyle boronic ester, phBO2C15H24, with (dichloromethyl) lithium has yielded to Cedranediol (R ) - 1 - Chloro- 1 - Phenylmetylboronate, phCHClBo2C15H24. The crystal structure of the complex belongs to orthorhombic system with spacegroup P212121 and cell parameters: a=5. 728(3), b=8. 543(3), c= 41. 267(7) A, V= 2019. 7A3 ; Z=4, Dcal= 1. 23g/cm3, μ(CuKa) = 17. 7cm-1, R=0.0072, Rw=0.0077.The result of crystal structure analyses shows that the product of asymmetric synthesis hashigh diastereomeric purity owing to the steric hinderance effect of cedranediol group.
关键词
雪松二醇硼酸酯
不对称合成
晶体
空间位阻效应
cedranediol boronic ester
asymmetric synthesis
crystal structure
steric hinderance effect