门诊外阴阴道假丝酵母菌病菌株调查和药敏分析

The Investigation and Analysis of Drug Sensitivity on Vulvovaginal Candidiasis Strains in Out-patients

目的探讨外阴阴道假丝酵母菌病(VVC)致病菌株分布和药敏情况。方法对2005年12月至2008年12月在孝感市中心医院妇科门诊以阴道炎症状就诊者中,阴道分泌物真菌培养阳性的260例患者进行菌株调查和药敏分析。结果VVC致病菌株白假丝酵母菌占89.6%(233/260),非白假丝酵母菌占10.4%,白假丝酵母菌菌株与非白假丝酵母菌菌株药敏无明显差异,两性霉素B药敏率98.87%。结论VVC致病菌株仍以白假丝酵母菌占优势,非白假丝酵母菌对两性霉素耐药率无增加。

Objective To evaluate the pathogenic candida species in vuvovaginal candidiasis and analyze antifungal sensitivity in vulvovaginal candidial strains. Methods Analyze candida species and antifungal sensitivity in 260 patients with symptomatic vulvovaginal candidiasis who were culture-positive for fungi in Central Hospital of Xiaogan from Dec 2005 to Dec 2008. Result Candida albicans accounted for 89.6% （233/260）, and nonalbicans accounted for10.4%.The antifungal sensitivity in vitro was different between monilia albicans and non-monilia albicans. Amphotericin B sensitivity in vitro was 98.87% respectively. Conclusion Candida albicam is still the most commonly identified species of pathogenic yeasts in VVC. Increased resistance to antifungal agents has not been observed in non-monilia albicans strains.