阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病的关系

Relationship of Obstructive Sleep Apnea-Hypopnea Syndrome with Gastroesophageal Reflux Disease

目的探讨阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病的关系。方法150例成年阻塞性睡眠呼吸暂停低通气综合征患者中男性127例、女性23例,其中合并胃食管反流病者78例。对胃食管反流病和非胃食管反流病者的症状积分、睡眠呼吸紊乱指数、身体质量指数进行比较;同时对轻度、中度、重度阻塞性睡眠呼吸暂停低通气综合征患者的例数、症状积分进行比较。结果具有胃食管反流病患者的上述三项指标均高于未诊断为胃食管反流病者;重度阻塞性睡眠呼吸暂停低通气综合征患者的例数较轻度和中度者高,但三者的症状积分无明显差别,经t检验,具有统计学意义(P<0.01)。结论阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病有密切关系。

Objective To investigate the relationship between obstructive sleep apnea-hypopnea syndrome and gastroesophageal reflux disease. Methods In 150 adult patients with obstructive sleep apnea-hypopnea syndrome, 127 was male and 23 was female,and 78 cases of the total were complicated with gastroesophageal reflux disease. Symptom score, apnea-hypopnea index （AHI） and body mass index（BMI）in these patients with and without gastroesophageal reflux disease were compared, and at the same time,the case number and the symptom score of mild,moderate and severe sleep apnea syndrome were analysed and compared. Results The aboved-mentianed three item indexes in the patients with gastroesophageal reflux disease were all higher than those in the patients without gastroesophageal reflux diseasea, and the cases of severe sleep apnea syndrome were more than those of mild and moderate sleep apnea syndrome. There was no significant difference in the symptom score of mild, moderate and severe sleep apnea syndrome, but a significant difference in t test（P〈 0.01 ）. Conclusion Obstructive sleep apnea syndrome has a close correlation with gastroesophageal reflux disease.