中枢神经细胞瘤临床病理分析

Central Neurocytoma:Analysis of Clinical Pathology

目的研究中枢神经细胞瘤(CNC)的临床病理特征,提高对此瘤的认识,避免误诊。方法分析6例CNC的临床病理特征,应用免疫组织化学染色方法检测其本质。结果本组病例肿瘤均发生于侧脑室。组织学特点:肿瘤由密集一致的小圆形细胞组成,瘤细胞有明显的核周空晕,呈蜂窝状结构。特征性改变为无核神经原纤维基质岛。免疫组织化学显示神经元核抗原NeuN及突触素Syn阳性;胶质纤维酸性蛋白GFAP及神经纤维细丝蛋白NF阴性。结论CNC是神经元形成的良性肿瘤,一般预后良好,免疫组织化学对确诊CNC很重要。

Objective To study the clinicopathological characteristics of central neurocytoma（ CNC ） so as to further realize the tumor and avoid misdiagnosis. Methods We analyzed the features of six cases by histopathological and immunohistochemical methods. Results The age of the six cases ranged from 17 to 36（average 25.8 years） with all tumors localized in the lateral ventricles. Histologically,all tumors were composed of small uniform round cells with clear cytoplasm and had a honeycomb pattern. The cell-free island of neuropil matrix was the most dominant feature. Immunohistochemical study demonstrated strong positive for NeuN and Syn,and negative for GFAP and NF. Conclusion CNC is a well-differentiated neuronal tumor. Its clinical behavior is considered benign and its prognosis is usually favorable. The importance of for its diagnosis is emphasized.