CD80和CD86分子参与带状疱疹发生的意义探讨

CD80 and CD86 Molecules Involved in the Occurrence of Herpes Zoster

目的探讨协同刺激分子CD80和CD86在带状疱疹发生与发展中的意义。方法采用流式细胞仪检测35例带状疱疹患者外周血淋巴细胞(peripheral blood lymphocytes,PBLC)表面CD80和CD86表达水平,并将患者临床特征纳入观察。结果带状疱疹患者PBLC表面CD80(t=5.14,P<0.001)和CD86(t=2.90,P<0.05)的表达水平与对照组相比显著降低;不同年龄组、病程组及病情组均无统计学意义。结论带状疱疹患者PBLC表面CD80和CD86的表达下调,通过B7/CD28协同刺激信号,抑制T细胞的活化,可能参与带状疱疹的发生。

Objective To study the significance of co-stimulatory molecule CD80 and CD86 in the occurrence and development of herpes zoster. Methods The expression of CD80 and CD86 on peripheral blood lymphocytes was measured by flow cytometric assay in 35 patients with herpes zoster. Results Decreasing of CD80 （ t=5.14, P〈0.001） and CD86 （ t=2.90, P〈0.05） ration was found in herpes zoster group as compared with the controls. But in different ages, courses and condition of patients, the difference of CD80 and CD86 was not found. Conclusion The expression of CD80 and CD86 on peripheral blood lymphocytes in patients with herpes zoster is down-regulated, which may be related with the occurrence of herpes zoster via B7/CD28 co-stimulatory signal.