耳鼻咽喉头颈部216例结外非霍奇金淋巴瘤的临床病理分析

Analysis on clinicopathologic characteristics of 216 primary extranodular non-Hodgkin's lymphoma in head and neck

目的:探讨耳鼻咽喉头颈部原发性结外非霍奇金淋巴瘤(NHL)的临床病理学特征。方法:回顾性分析216例头颈部NHL患者的临床病理学资料。结果:本组样本年龄分布有2个高发段,分别为31～60岁和71～80岁;最常见的原发部位为鼻腔95例(44.0%),其次为扁桃体47例(21.8%);最常见的组织学类型为NK/T细胞淋巴瘤107例(49.5%),其次为弥漫性大B细胞淋巴瘤58例(26.7%)。按部位统计发病率最高的组织学类型分别为:鼻腔为NK/T细胞淋巴瘤74例(77.9%),鼻窦为弥漫性大B细胞淋巴瘤6例(50.0%),扁桃体为弥漫性大B细胞淋巴瘤27例(57.4%),鼻咽口咽为NK/T细胞淋巴瘤17例(44.7%),舌根为弥漫大B细胞淋巴瘤5例(45.4%)。结论:耳鼻咽喉头颈部原发性NHL是一类比较常见的疾病,其在发病年龄、原发部位和组织学类型上都具有明显的临床病理学特征,对临床病理诊断有较大的帮助。

Objective：To study the clinicopathologic characteristic of the primary extranodular non-Hodgkin＇s lymphoma in head and neck. Method：Clinical manifestation and the characteristic of clinicopathology of 216 extranodular non-Hodgkin＇s lymphoma patients in head and neck were analyzed retrospectively. Result：The age of thirtyone to sixty and seventy-one to eighty years old were more common age range in the group of patients. Nasal cavity was the most commonly primary involved site（95 cases, 44.0% ） , secondly was tonsil （ 47 cases, 21. 8%）. The most common histologic subtype was NK/T cell lymphoma, which accounted for 49.5% （107 cases）of cases, secondly was diffuse large B cell lymphoma （DLBCL, 58 cases, 26.7%）. The most common histologic subtype in different swtach groups respectively is： NK/T cell lymphoma in nasal cavity（74 cases, 77.9%）, DLBCL in para- nasal sinus（6 cases, 50.0 G ）, DLBCL in tonsil（27 cases, 57.4 %）, NK/T cell lymphoma in nasopharynx（17 cases, 44.7%）, and DLBCL in lingual root（5 cases, 45.4%）. Conclusion： We conclude that primary extranodular non- Hodgkin＇s lymphoma is common in head and neck patients. There is characteristic in age, primary involved site and histologic subtype, which is helpful to understand these characteristic for pathologic diagnosis.