COX-2和VEGF-C在甲状腺乳头状癌中的表达及与颈淋巴结转移的关系

Expression of COX-2 and VEGF-C in papillary thyroid carcinoma and their relationship to cervical lymph metastases

目的:探讨环氧化酶-2(COX-2)和血管内皮生长因子-C(VEGF-C)在甲状腺乳头状癌组织中的表达及与颈淋巴结转移的关系。方法:应用免疫组织化学方法检测40例甲状腺乳头状癌组织中COX-2和VEGF-C的表达情况,并进行颈淋巴结转移相关性分析。结果:甲状腺乳头状癌组织中COX-2和VEGF-C的表达阳性率分别为70.0%(28/40)和75.0%(30/40),其中颈淋巴结转移组COX-2和VEGF-C的表达阳性率分别为80.8%(21/26)和84.6%(22/26),无颈淋巴结转移组分别为50.0%(7/14)和57.1%(8/14),两组之间差异均有统计学意义(P<0.05)。甲状腺乳头状癌组织中COX-2和VEGF-C之间表达呈正相关(r=0.378,P<0.05)。结论:COX-2和VEGF-C在甲状腺乳头状癌组织中高表达且关系密切,两者在甲状腺乳头状癌颈淋巴结转移中发挥作用且可能有协同效应。

Objective： To investigate the expression of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor-C （VEGF-C） in papillary thyroid carcinoma and their relationship to cervical lymph metastases. Method：In this study, the expressions of COX-2 and VEGF-C were examined by immunohistochemistry in papillary thyroid carcinoma tissues of 40 patients, and analysis was performed on the correlation of cervical lymph metastases with COX-2 and VEGF-C expression. Result： Positive expressions of COX-2 and VEGF-C were 70.0 % （28/ 40）and 75.0% （30/40）respectively in papillary thyroid carcinoma. The positive rates of COX-2 and VEGF-C expression were 80. 8% （21/26）and 84. 6% （22/26）respectively in patients with cervical lymph metastases, and 50.0% （7/14）and 57.1 % （8/14）respectively in patients without cervical lymph metastases, with a statistically sig- nificant difference between two groups（P〈0.05, all）. COX-2 was positively correlated to VEGF-C expression in papillary thyroid carcJnoma（r=0. 378, P〈0. 05）. Conclusion： The results suggest that COX-2 and VEGF-C were highly expressed in papillary thyroid carcinoma, with possible interaction of their expressions, and may play a critical role in the cervical lymph metastases of papillary thyroid carcinoma.