Combretastatin A4磷酸酯二钠抑制血管生成作用的研究

Study on antiangiogenesis effect of Combretastatin A4P

目的探讨Combretastatin A4磷酸酯二钠(CA4P)对血管生成的影响。方法建立鸡胚绒毛尿囊膜(CAM)模型及兔角膜新生血管(CNV)模型,评价CA4P对两种模型中血管生成的影响。结果与对照组相比,CA4P高、中剂量具有明显的抑制CAM血管生成的作用(P<0.01或P<0.05);CA4P各剂量对CNV也显示了不同程度的抑制作用(P<0.01或P<0.05)。结论CA4P具有抑制血管生成的作用。

OBJECTIVE To study the antiangiogenesis effect of Combretastatin A4 （CA4P）. METHODS CAM and CNV models were established to evaluate the effect of CA4P on the angiogenesis. RESULTS Compared with NS group, the angiogenesis in the CAM which were treated with high dose and middle dose of CA4P had been obviously inhibited（P 〈 0.01 ）. The angiogenesis in CNV which were treated with three doses of CA4P had also been inhibited （ P 〈 0.01 ）. CONCLUSION CA4P has the antiangiogenesis effect.