2,5-脱水-3,4,6-O-三苄基-D-葡萄糖醇的改进合成方法(英文)

Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol

目的:改进2,5-脱水-3,4,6-O-三苄基-D-葡萄糖醇的合成方法。方法:以D-甘露醇为原料构建2,5-脱水-3,4,6-O-三苄基-D-葡萄糖醇的手性分子骨架,通过选择性地对多羟基的保护和脱保护达到对产物分离的目的。结果:本合成路线通过对已知路线的改进,以D-甘露醇为原料,通过7步反应制备了2,5-脱水-3,4,6-O-三苄基-葡萄糖醇,总收率8.3%。结论:该合成方法反应条件温和后处理简单,是一条经济的合成路线。

Aim： To improve the synthesis for 2, 5-anhydro-3, 4, 6-tri-O-benzyl-D-glucitol. Methods： Dehydrahon of D-mannitol, followed by a reaction sequence of selective protection, benzylation, deprotection, tritylation, benzylation and removal of the trityl group, afforded the title compound. Results： Based on the improvement of the reported synthetic route, 2, 5-anhydro-3, 4, 6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8.3%. Conclusion： This new method features mild reaction conditions and facile work -up.