美托洛尔62例不良反应及合理用药

Metoprolol-induced Adverse Drug Reactions of 62 Cases and Analysis of Rational Drug Use

目的:通过对美托洛尔62例临床不良反应病例进行分析,为临床合理用药提供参考。方法:针对2001年9月至2007年11月62例我院住院患者因使用美托洛尔而出现不良反应,进行分类统计和分析。结果:美托洛尔的不良反应与其阻断β受体有关。其中以心血管系统不良反应最为常见,消化系统不良反应和变态反应次之,所占比例分别为48.39%(30/62)、12.90%(8/62)、12.90%(8/62)。结论:美托洛尔作为新一代高选择性的β受体阻滞剂,疗效显著,但其伴随的不良反应日益突出,需要医师和药师密切关注,合理用药,减少和避免不良反应的发生。

OBJECTIVE： To analyze Metoprolol-induced adverse drug reactions（ADRs）（in 62 cases）in order to provide reference for clinical rational medication of Metoprolol.METHODS： A total of 62 Metoprolol-induced ADR cases collected from our hospital from Sept.2001 to Nov.2007 were analyzed statistically.RESULTS： Metoprolol-induced ADRs might be related to its blocking on β-receptors.48.39%（30/62）of the Metoprolol-induced adverse reactions were seen in cardiovascular system,12.90%（8/62）in gastrointestinal system and 12.90% （8/62）appeared as allergic reactions.CONCLUSION ： Metoprolol as a new generation of highly selective β - blocker has remarkable curative efficacy, however, the accompanying increasingly prominent adverse reactions worth the highest alert of both physicians and pharmacists. Metoprolol should be used rationally so as to reduce and avoid the occurrence of adverse reactions.