胺碘酮对阵发性房颤患者P波离散度及高敏C-反应蛋白和脑钠肽的影响

Effect of Amiodarone on P wave dispersion and high sensitive C-reactive protein and brain natriuretic peptide in patients with paroxysmal atrial fibrillation

目的观察胺碘酮对阵发性房颤患者P波离散度及高敏C-反应蛋白（hs—CRP）和脑钠肽（BNP）的影响。方法56例阵发性心房颤动患者作为观察组，31例健康体检者作为对照组。治疗前及经胺碘酮治疗3个月后测定P波离散度，取血测定hs—CRP和BNP水平。结果治疗前观察组P波离散度与对照组比较差异有统计学意义（P〈0．05）；治疗后观察组的P波离散度减少30．9％，两组的变化值差异有统计学意义（P〈0．05）。治疗前观察组hs—CRP和BNP水平均比对照组显著增高（P〈0．05），治疗后hs—CRP和BNP水平分别降低50．9％和16．5％；两组间二者的变化值差异有统计学意义（P〈0．05）。结论胺碘酮可使阵发性房颤患者P波离散度减小，使增高的hs—CRP和BNP水平显著降低。

Objective To observe the effect of Amiodarone on P wave dispersion and high sensitive C-reactive protein （hs-CRP） and brain natriuretic peptide （BNP） in patients with paroxysmal atrial fibrillation. Methods 56 cases patients with paroxysmal atrial fibrillation were regarded as observation group,31 cases people of health examination were regarded as control group. P wave dispersion and hs-CRPs and BNPs were determined pretherapy and after 3 months through Amiodarone treatment. Results Compared with control group, P wave dispersion of observation group was significant difference pre-therapy （P〈0.05）. P wave dispersion of observation group reduced 30.9% post -treatment than pretherapy, change values of two groups had statistically significant difference （P〈0.05）. hs-CRPs and BNPs of pretherapy in observation group than control group were prominent increase （P〈0.05）, but hs-CRPs and BNPs level in observation group respectively lower 50.9% and 16.5% posttreatment than pretherapy, and change values of two groups were statistically significant difference （P〈0.05）. Conclusion Amiodarone could reduce P wave dispersion in patients with paroxysmal atrial fibrillation,and decrease hs-CRPs and BNPs level.