主动脉瓣退行性变的危险因素研究

Study of the correlative factors of aortic valve degeneration

目的探讨主动脉瓣退行性变（AVD）的危险因素。方法336例因怀疑冠心病的住院患者，根据超声心动图结果分为AVD组和非AVD组，比较两组年龄、性别、吸烟、冠心病家族史、糖尿病、高血压病、体重指数、血压、空腹血糖、血脂、血尿酸、血清总胆红素、血清总胆汁酸、颈动脉硬化（CAS）情况，做统计学分析。结果两组患者年龄、吸烟、糖尿病、高血压病、体重指数、收缩压、总胆固醇、低密度脂蛋白胆固醇（LDL—C）、尿酸、CAS等因素统计学分析差异有统计学意义（P〈0．05，P〈0．01），多元逻辑回归显示，年龄、糖尿病、LDL—C、CAS是AVD的独立危险因素。结论主动脉瓣退行性变与多种心血管疾病的危险因素有关，年龄、糖尿病、LDL—C、CAS是AVD的独立危险因素，提示AVD和动脉粥样硬化可能有着共同的易患因素和发病基础，相似的发病机制。

Objective To study the risk factors of aortic valve degeneration （AVD）. Methods Totally 336 patients were divided into no AVD （NAVD） group and AVD group according to echocardiography. Some possi- ble risk factors including age, sex, smoking, hypertension, diabetes, serum lipid, family CAD history, BMI, CAS, GLU, UA, TBA and TBIL were analyzed. Results There was significant difference in age, smoking, hypertension, diabetes, SBP, BMI,TC, LDL-C, UA and CAS between AVD group and NAVD group （P〈0.05, P〈 0.01 ）. Multivariate logistic regression analysis revealed that age, diabetes, high serum LDL-C and CAS were independent risk factors of AVD. Condusion Aortic valve degeneration is correlated with multiple risk factors of cardiovascular diseases and may have mutual pathological basis with atheroselerosis.