慢性肾脏疾病3,4,5期中医证候学的临床研究

TCM symptomatology of chronic kidney disease in the third,fourth and fifth stage

目的观察慢性肾脏疾病(CKD)3,4,5各期的中医证候分布情况。方法选择慢性肾脏疾病患者290例,根据中医辨证分型观察正虚证和标实证在CKD3,4,5各期分布情况及正虚标实证兼夹分布情况。结果CKD3期正虚证中脾肾气虚出现频率最高,标实证中湿热出现频率最高;CKD4,5期正虚证中脾肾阳虚出现频率最高,标实证中湿浊出现频率最高。结论CKD3,4,5期正虚证的演变遵循由脾肾气虚到脾肾阳虚的规律。标实证主要为湿热、湿浊和血瘀。

Objective To observe the distribution of TCM symptoms of chronic kidney disease （CKD） in the third, fourth and fifth stage. Method The distributions of the syndrome of heahhy-qi deficiency, syndrome of tip excess and syndrome of healthy-qi deficiency complicated with tip excess were observed, according to TCM syndrome differentiation and classification, in 290 patients with CKD in the third, fourth and fifth stage. Result The occurrence rate of spleen-kidney qi deficiency was the highest in the syndrome of heahhy-qi deficiency, and that of dampness heat was highest in the syndrome of tip excess in the third stage of CKD. The occurrence rate of spleen-kidney yang deficiency was the highest in the syndrome of heahhy-qi deficiency, and that of dampness turbidity was the highest in the syndrome of tip excess in the fourth and fifth stage of CKD. Conclusion The syndrome of heahhy-qi deficiency of CKD in the third, fourth and fifth stage develops from spleen-kidney qi deficiency to spleen-kidney yang deficiency. The syndrome of tip excess includes mainly dampness heat, dampness turbidity and blood stasis.