普伐他汀对不稳定型心绞痛患者血清妊娠相关蛋白-A和细胞因子的影响

Effects of pravastatin on serum concentration of PAPP-A and cytokines in patients with unstable angina pectoris

目的探讨普伐他汀对不稳定型心绞痛患者血清妊娠相关蛋白-A(pregnancy-associated plasma protein-A,PAPP-A)和细胞因子的影响。方法测定50例常规治疗组和50例普伐他汀治疗组不稳定型心绞痛患者治疗前后血清PAPP-A、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、间质金属蛋白酶9(matrix metalloproteinases-9,MMP-9),以及低密度脂蛋白胆固醇(low-density lipoprotein,LDL-C)浓度,所得结果进行统计分析。结果普伐他汀组治疗12周后血清PAPP-A、TNF-α、IL-6、MMP-9及LDL-C浓度均较治疗前明显降低(P<0.05),而常规治疗组治疗前后血清PAPP-A、TNF-α、IL-6、MMP-9及LDL-C浓度差异无统计学意义(P>0.05)。普伐他汀组血清PAPP-A、TNF-α、IL-6、MMP-9浓度和LDL-C浓度无相关性(r=0.10,P>0.05;r=0.02,P>0.05;r=0.08,P>0.05;r=0.05,P>0.05)。结论普伐他汀可以降低不稳定型心绞痛患者血清PAPP-A和细胞因子浓度,减轻炎症反应,稳定冠脉粥样硬化斑块,并且这种机制独立于降脂作用以外。

Objectives To investigate the effects of pravastatin on serum concentration of PAPP-A and cytokines in patients with unstable angina pectoris. Methods We measured the serum concentrations of pregnancy-associated plasma protein-A （PAPP-A）, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, matrix metalloproteinases-9 （MMP-9） and low-density lipoprotein-C （LDL-C） before and after treatment in 50 cases of traditional treatment group and 50 cases of pravastatin group. Results Compared with before treatment, the serum concentrations of PAPP- A, TNF-α, IL-6, MMP-9 and LDL-C in pravastatin group significantly decreased after 12 weeks of treatment （P〈 0.05）. However, there was no significant difference between serum concentrations of PAPP-A, TNF-α, IL-6, MMP- 9 and LDL-C in patients of traditional treatment group after and before treatment （P〉0.05）. There was no significant correlation between the serum concentrations of PAPP-A, TNF-α, IL-6, MMP-9 and the serum concentrations of LDL-C （r=0.10, P〉0.05; r=0.02, P〉0.05; r=0.08, P〉0.05; r=0.05, P〉0.05） in pravastatin group. Conclusions Pravastatin can lower the serum concentrations of PAPP-A and cytokines in patients with unstable angina pectoris, restrains inflammation response, and stabilizes the coronary atheroselerosis plaque. The mechanism may be independent of the function of lowering cholesterol.