利培酮与氯氮平治疗精神分裂症对照研究

Effect of risperidone and clozapine on the treatment of schizophrenia

目的比较利培酮和氯氮平治疗精神分裂症的疗效和不良反应。方法将40例精神分裂症患者随机分成两组，利培酮组和氯氮平组各20例，于治疗前和治疗第2、4、6周末采用症状量表（PANSS）及副反应量表（TESS）评定疗效及不良反应。结果两组PANSS减分率比较差异无统计学意义（P〉0．05），利培酮组不良反应少。结论利培酮与氯氮平治疗精神分裂症疗效相当，但利培酮不良反应少。

Objective To comparie effect of risperidone and clozapine on the treatment of schizophrenia and adverse reactions. Methods 40 cases were randomly divided into two groups of patients with schizophrenia, risperidone and clozapine group 20 cases, pre-treatment and treatment in the first weekend 2,4,6 Symptom Rating Scale （PANSS） and the reaction volume Table （TESS） were used to assess the efficacy and adverse reactions. Results Comparison of reduction rate PANSS, there was no significant difference（ P 〉 0.05 ）, compared with clozapine group, risperidone group had less adverse reactions. Conclusion Risperidone and clozapine group had considerable effect in the treatment of schizophrenia, but risperidone had fewer adverse reactions.