血培养标本中病原菌的种类分布及其耐药性分析

Distribution and drug Resistance of Pathogens Isolated from Blood Samples

目的探讨医院血培养病原菌的分布特点及其耐药情况,为临床诊疗提供参考。方法利用WHONET5.4对2005年1月-2008年6月的所有血培养标本进行回顾性分析。结果送检的8106份血培养标本中,检出病原菌875株,阳性率为10.8%,革兰阳性球菌占48.3%,革兰阴性杆菌占45.7%,真菌占8.3%;检出率最高的病原菌分别是凝固酶阴性葡萄球菌(CNS)和马尔尼菲青霉菌(PM)。结论血培养中分离出的病原菌种类复杂,各种病原菌的耐药性各有不同,艾滋病患者血培养中PM感染率较高为广西血培养特点;应加强血培养中病原菌及其对抗菌药物的耐药性监测。

OBJECTIVE To explore the isolated bacteria and their drug resistance from blood culture samples in our hospital. METHODS A retrospective analysis was made to the blood culturing results during the period of Jan 2005 to Jun 2008 with WHONET 5.4 software. RESULTS Among the 8106 blood samples, 875 strains of pathogens were isolated （10.8%） . 48.3% were Gram-positive cocci,45. 7% were Gram-negative bacilli,and 8. 3% were fungi. The main pathogens in bacteremia were coagulase-negative staphylococci and the main fungi were Penicillium marneffei. CONCLUSIONS The kinds of isolated bacteria are complex from the positive blood cultures and their drug resistance rates were different. A high infection rate of P. marneffei in AIDS is the feature in our region. More attention should be paid to the detection and surveillance of bacterial resistance in blood culture.