珊瑚羟基磷灰石人工骨修复骨干缺损的生物力学评估

Biomechanics Study of Coralline Hydroxyapatite(CHA) as Bone Graft Substitute in Animal Experiment

本研究目的是评估CHA修复骨干缺损的生物力学能力．将天然海珊瑚碳酸钙经过“热液交换反应”制成珊瑚羟基磷灰石人工骨．X线衍射分析其晶相为Ca（PO）OH；扫描电镜观察为多孔隙结构，测得孔隙直径平均200μm，孔隙率53％；硬度为Mohs5度．用12只新西兰兔为实验动物，植入材料16周取材做生物力学实验，测得尺骨标本的最大扭矩分别为：人工骨组52．04N／cm，自体骨移植组34．88N／cm，正常骨组61．10N／cm．证明珊瑚羟基磷灰石人工骨与宿主骨结合能力强，意合后强度优异，适合于长骨缺损的修复．

The bone graft substitute of coralline hydroxyapatite (CHA) was made from coral skeletal carbonate through hydrothermal exchange at specificed condition. The material's phase identification measured by X-ray diffraction is Ca5(PO4)aOH. A porous structure of 200μm in pore diameter. and 53% porosity was observed by SEM. Mohs hardness is 5. Biomechanical test of bone specimens in 16 weeks was done after implant it to 12 New Zealand white rebbits. The maximum torques are respectively 52.0N.cm. 34.9N.cm and 61.1N.cm in the artificial bone group, the autograft group and the control group. CHA artificial bone has a good bonding strength with host bones and is suitable for the repair of segmental diaphyseal defect.