IGF-I、OPN、PTEN蛋白在非小细胞肺癌中的表达及其意义

Significance of Expression of IGF-I,OPN and PTEN Protein in Non-small Cell Lung Cancer

探讨胰岛素样生长因子1(IGF-I)、骨桥蛋白(OPN)和PTEN在人非小细胞肺癌中的表达及其相关性,并分析其与非小细胞肺癌的关系。应用免疫组织化学SP法检测61例肺癌组织和30例癌旁组织中IGF-I、OPN、PTEN的表达情况。结果显示,①肿瘤组织中IGF-I、OPN蛋白表达显著高于癌旁组织(P<0.05),IGF-I的表达与肿瘤分化程度、淋巴结转移有关(P<0.05),OPN的表达与患者肿瘤分化程度、淋巴结转移、TNM分期有关(P<0.05),肿瘤组织中PTEN蛋白表达明显低于癌旁组织(P<0.05),PTEN的表达与肿瘤大小、肿瘤组织的分化程度、有无淋巴结转移有关(P<0.05)。②IGF-I的表达与OPN的表达呈正相关(P<0.05),IGF-I、OPN与PTEN的表达呈负相关(P<0.05)。研究表明,IGF-I、OPN、PTEN蛋白与非小细胞肺癌的发生发展密切相关,三者的表达对判断肺癌恶性程度和预后具有参考意义。

To investigate the expressions of IGF-I, OPN and PTEN and their correlation with prognosis in Non-Small Cell Lung Cancer （NSCLC）, immunohistochemical staining was used to identify the expression of IGF-I, OPN and PTEN in 61 cases of NSCLC and 30 cases of adjacent non-cancer tissues. In NSCLC cases, the expressions of IGF-I and OPN were higher than those in the adjacent non-cancer tissues （P〈0.05）. The positive rates of IGF-I were closely correlated with the stage of tumor and lymph node metastasis. The positive rates of OPN were closely correlated with the grade of differentiation, lymph node metastasis and TNM staging. In NSCLC cases, the expression of PTEN was lower than those in the adjacent non-cancer tissues （P〈0.05）, the positive rates of PTEN was closely correlated with size of tumor, the grade of differentiation and lymph node metastasis （P〈0.05）. The expression of IGF-Iwas correlated positively with that of OPN （P〈0.05）. The expression of IGF-I and OPN were correlated negatively with that of PTEN （P〈 0.05）. It is concluded that the expressions of IGF-I, OPN and PTEN are related to the occurrence and progression of NSCLC. And they may serve a valuable index for diagnosing the malignant extent and prognosis of lung cancer