术中输注聚明胶肽对术后外周血小板CD_(41)含量的影响

Postoperative change of CD_(41) content in peripherhl platelet following intra-operative polygeline administration

目的:探讨术中输注聚明胶肽对下腹部手术患者术后血小板活化分子CD_(41)含量的影响。方法:将68例择期行下腹部手术患者,随机分成试验组和对照组,每组34例,试验组输注聚明胶肽1 000ml,对照组输注平衡液1 000ml。术前1天,术后1小时、1天、2天、5天抽外周血,用流式细胞免疫学方法,检测CD_(41)含量。结果:两组术前无显著差异。而术后1小时及1天聚明胶肽组CD_(41)含量明显低于对照组(P<0.01)。但两组术后1小时至5天CD_(41)含量均明显高于术前水平(P<0.01)。结论:手术可导致术后CD_(41)含量明显增高,输注聚明胶肽可降低术后CD_(41)含量。

Objective: To investigate the postoperative change of concentration of CD_(41) in peripheral platelet following intra-operative polygeline administration. Method: Sixty-eight patients were randomly divided into studied and control groups. The patients in studied group were infused with 1 000ml polygeline whereas 1 000ml ringer's solution in control group. The concentration of CD_(41) in peripheral platelet was measured with immunocytometry before surgery, one hour, one day, two and five days after surgery. Result: There was no statistical difference in CD_(41) level between the two groups before surgery, CD_(41)values one hour and one day after surgery were obviously decreased in studied group compared with these in control group (P<0.01); The postoperative CD_(41) content was kept at higher level than baseline during whole procedures in both groups. Conclusion: CD_(41) content increase may result from surgery. Intra-operarive polygeline may be helpful in reducing CD_(41) level in peripheral platelet.